![]() Both made test subjects too sick to reveal any secrets so the OSS researchers settled instead on marijuana, using a tasteless, colorless, and odorless liquid extract called TD that could be injected into an unwitting target’s cigarettes. The OSS first tried out mescaline, a hallucinogenic cactus derivative they also experimented with scopolamine, a “twilight sleep” drug that had experienced a vogue as a truth serum in the 1920s and 1930s. ![]() ![]() In 1942, as World War II raged, the United States’ newly established spy agency, the Office of Strategic Services (OSS), asked its scientists to turn their attention from their other projects to the urgent mission of creating a truth drug to interrogate prisoners of war.
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